USP Chapter <86> due to come into effect in May 2025, endorses the general use of recombinant reagents for BET.

FUJIFILM Recombinant BET Reagent PYROSTAR™ Neo+ is a new endotoxin detection reagent developed by recombinant technology.

PYROSTAR™ Neo+ is a lyophilized reagent that combines 3 recombinant factors (factor C, factor B, proclotting enzyme) with sequences derived from Limulus polyphemus and a chromogenic substrate (peptidyl pNA).

The PYROSTAR™ Neo+ is a highly sensitive and specific assay for detection of bacterial endotoxin.