Novogene's Microbial Research

• Identifies microbial organisms from pathogens to positive contributors to agriculture, human health, waste treatment, and biopharmaceutical production.
• Establishes high-flux, large-scale gene sequencing and high-performance computing platforms.
• Expertise in microbial library preparation, sequencing, and bioinformatic analysis.
• Blogs showcase practical applications of microbial sequencing to solve real-world challenges.

Microbial organisms range from pathogens that cause infectious diseases of serious public health concern to microbes that make important positive contributions to agriculture, human health, waste treatment, and the industrial production of biopharmaceuticals.

Novogene has established high-flux, large-scale gene sequencing, and high-performance computing platforms. We have developed extensive expertise in microbial library preparation, sequencing, and bioinformatic analysis across numerous species and seek to share this information with the scientific community. The blogs, summarized below, showcase the practical applications of these methods using published examples of microbial sequencing to solve real-world challenges. 

1. 16S rRNA and shotgun: approaches to metagenomics
Culture-based techniques reveal only a subset of the total number of organisms in most microbial communities. 16s rRNA and shotgun sequencing have revolutionized the study of environments and complex microbial communities. 

• Choosing the correct region of 16S rRNA to amplify is critical to obtaining a representative outcome.
• Shotgun metagenomic sequencing reduces amplification bias compared to rRNA gene sequencing.
• Whole genome sequencing can resolve at the species and subspecies level.

2. Metagenomics and amplicon sequencing revealed soil biodiversity
Metagenomics and amplicon sequencing have revolutionized the study of complex microbial communities, revealing population biodiversity such as those in environmental samples, including soil, sludge, seabed sediments, and fermentation processes.

• Metagenomic analysis can be used to study microbial diversity within numerous microbial communities.
• This technology allows us to observe the effects of various treatments and conditions on the microbiome's composition.
• It is critical for the study of unculturable microorganisms.

3.  The correlations between gut microbes and human health
Sequencing has played a key role in discovering that the gut microbiota is essential to maintaining human and animal health. Sequencing elucidates gut microbiota composition, including extremely low-abundance microbial constituents, allowing accurate correlations between gut microbes and human or animal health.

• Genetic studies reveal microbes' crucial role in host metabolism, physiology, and immunology.
• These technologies are key to determining the effect of diet on gut microbiome composition.

Novogene continues to provide our clients with premium-quality and cost-effective pricing services. We welcome you to consider how our services can overcome your challenges and work with us to accomplish your goals. Contact us to understand which application is right for your microbiome studies.