The ESCMID^[1] guidelines on C. difficile state that a multistep algorithm should be used in C. difficile diagnosis and can help differentiate asymptomatic carriers from people with true C. difficile infection. The algorithm begins with a highly sensitive screen, such as GDH or PCR, followed by a toxin enzyme immunoassay (EIA).

The C. DIFF QUIK CHEK COMPLETE^® rapid EIA assay is cited by name as an assay that simultaneously detects GDH and toxin. One single cassette completes the multistep algorithm for accurate, rapid, cost-effective C. difficile testing.

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1. Crobach MJ, Planche T, Eckert C, Barbut F, Terveer EM, Dekkers OM, Wilcox MH, Kuijper EJ. European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile Clin Microbiol Infect. 2016 Aug;22 Suppl 4:S63-81. doi: 10.1016/j.cmi.2016.03.010. Epub 2016 Jul 25. PMID: 27460910.